2H-1,4-Benzoxazin-3(4H)-one, 8-[(1R)-2-chloro-1-hydroxyethyl]-6-(phenylmethoxy)- - Names and Identifiers
2H-1,4-Benzoxazin-3(4H)-one, 8-[(1R)-2-chloro-1-hydroxyethyl]-6-(phenylmethoxy)- - Physico-chemical Properties
| Molecular Formula | C17H16ClNO4
|
| Molar Mass | 333.77 |
| Density | 1.351±0.06 g/cm3(Predicted) |
| Boling Point | 564.0±50.0 °C(Predicted) |
| pKa | 12.09±0.20(Predicted) |
2H-1,4-Benzoxazin-3(4H)-one, 8-[(1R)-2-chloro-1-hydroxyethyl]-6-(phenylmethoxy)- - Upstream Downstream Industry
2H-1,4-Benzoxazin-3(4H)-one, 8-[(1R)-2-chloro-1-hydroxyethyl]-6-(phenylmethoxy)- - Introduction
6-benzyloxy-8-((R)-2-chroo-1-hydroxy-ethyl)-4H-benzo[1,4]-oxazin-3-one is an organic compound with the chemical formula C18H16ClNO3.
Nature:
-Appearance: Colorless to white crystal or powder
-Melting point: approximately 125-128 ° C
-Solubility: Soluble in common organic solvents (such as methanol, ethanol and dichloromethane), insoluble in water.
Use:
- 6-benzyloxy-8-((R)-2-chloroo-1-hydroxy-ethyl)-4H-benzo[1,4]-oxazin-3-one is commonly used as an intermediate in organic synthesis and can be used to synthesize a variety of biologically active compounds.
-It can also be used in the fields of dyes, medicine and pesticides.
Method:
A method for preparing 6-benzyloxy-8-((R)-2-chloro-1-hydroxy-ethyl)-4H-benzo[1,4]-oxazin-3-one involves the following steps:
1. By a suitable method, 4H-benzo [1,4]-oxazine is condensed with an appropriate condensation reagent to yield 6-benzyloxy-4H-benzo [1,4]-Oxazine.
2. 6-benzyloxy-4H-benzo [1,4]-oxazine is treated with hydrofluoric acid for deprotection reaction to generate 4, 6-Dibenzyl-2-oxobenzo [1,4]-oxazine.
3. Under appropriate reaction conditions, 4,6-dibenzyl-2-oxobenzo [1,4]-oxazine is reacted with chloroacetate, 6-Benzyloxy-4, 6-dibenzyl-2-chlorobenzo [1,4]-oxazine is produced.
4. Finally, 6-benzyloxy-4, 6-dibenzyl-2-chlorobenzo [1,4]-oxazine reacts with an appropriate nucleophile (such as a hydroxyl compound) under the action of a base to undergo a substitution reaction to generate the target compound 6-benzyloxy-8-((R)-2-chloroo-1-hydroxy-ethyl)-4H-benzo[1,4]-oxazin-3-one.
Safety Information:
Specific safety information about 6-benzyloxy-8-((R)-2-chloroo-1-hydroxy-ethyl)-4H-benzo[1,4]-oxazin-3-one should be carefully reviewed in the product literature and relevant safety data sheets. Appropriate personal protective equipment and laboratory safety should be used when handling the compound.
Last Update：2024-04-09 21:54:55